Though Panels comes with several built-in layouts for you to choose from, you’ll find that these don’t always suit your needs. Fortunately, there’s also a layout designer that anyone can use to create a new layout with Panels. In this lesson you will learn how to use the Panels layout designer for rapid prototyping.
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This video covers a topic in Drupal 7 which may or may not be the version you're using. We're keeping this tutorial online as a courtesy to users of Drupal 7, but we consider it archived.